The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical Study

Background: LGR5 is one of the most important stem cell markers for colorectal cancer (CRC), as it potentiates Wnt/Β-catenin signaling. The well-characterized deregulation signaling that occurs during adenoma/carcinoma sequence in CRC renders a hopeful therapeutic target. We assessed immunohistochemical expression and Β-catenin normal colonic tumorous lesions with clinicopathological correlation. Methods: Tissue blocks clinical data 50 selected cases were included: 8 from mucosa, 12 adenoma, 30 CRC, where sections cut re-examined technique was conducted using anti-LGR5 anti-Β-catenin to measure staining density. Results: There no mucosa compared samples adenoma samples. association analysis showed specimens more likely have strong expressions than other two groups (p = 0.048 p < 0.001, respectively). Specimens high-grade dysplastic express moderate-to-strong 0.013 0.036, In contrast, there statistically significant associations between grade stage. Conclusion: These results suggest support possible role potential marker cells sporadic carcinogenesis addition prognostic value adenomatous according A suggested future studies based on its pathogenesis.